What is an active folate:
The terms “folic acid” and “folate” both derive from the Latin “folium”, which means leaf and are two ways of indicating vitamin B9. In fact, leafy vegetables are among the best dietary sources of folates.
Although frequently “folic acid” and “folates” are used as synonyms, the two terms must be distinguished.
While folate is the vitamin in its biologically active and natural form, folic acid is the synthetic form of folates. Therefore Folipram is the biologically active form of folate, which is naturally present in our body and represents 98% of plasma folates.
Folipram does not need to be biotransformed by the methylene-tetrahydrofolatoreductase enzyme (MTHFR). Therefore, with its intake, its bioavailability is not limited by the saturation of this enzyme and its intake does not involve the presence of non-metabolized forms of folate in the blood.
Folipram is the metabolically active form of folic acid and is able, through the transfer of a methyl group, to reconvert homocysteine into methionine and to perform all the biological and health functions of folate even in the presence of a genetic deficit.
What is an active folate:
The terms “folic acid” and “folate” both derive from the Latin “folium”, which means leaf and are two ways of indicating vitamin B9. In fact, leafy vegetables are among the best dietary sources of folates.
Although frequently “folic acid” and “folates” are used as synonyms, the two terms must be distinguished.
While folate is the vitamin in its biologically active and natural form, folic acid is the synthetic form of folates. Therefore Folipram is the biologically active form of folate, which is naturally present in our body and represents 98% of plasma folates.
Folipram does not need to be biotransformed by the methylene-tetrahydrofolatoreductase enzyme (MTHFR). Therefore, with its intake, its bioavailability is not limited by the saturation of this enzyme and its intake does not involve the presence of non-metabolized forms of folate in the blood.
Folipram is the metabolically active form of folic acid and is able, through the transfer of a methyl group, to reconvert homocysteine into methionine and to perform all the biological and health functions of folate even in the presence of a genetic deficit.
THE ACTIVE AND EFFECTIVE FOLATE
FOLIPRAM is the biologically active form of folate which can be used without any metabolic activation. FOLIPRAM is easily absorbed and is immediately active for its biological effects.
ASK YOUR TRUSTED PHARMACIST FOR FOLIPRAM
F.A.Q.
The water-soluble vitamin that constitutes folate (vitamin B9) is important as it acts in favor of the synthesis of DNA which regulates cell division. In the case of rapid growth, and therefore in particular at the beginning of pregnancy, the need for folic acid increases. In general, moreover, this vitamin participates in the biosynthesis of many substances useful for health.
A folic acid deficiency occurs in women mainly in the form of anemia and an increase in homocysteine levels in the blood.
The intake of active folates before pregnancy is highly recommended as it is essential in the production of new cells. Their deficiency could compromise the normal evolution of an embryo and, in particular, the formation of the vertebral column and spinal cord. It is therefore essential to prevent birth defects.
In pregnancy, therefore, in addition to improving your lifestyle by following a healthy diet, it is important to take a folic acid supplement. The folates present in Folipram are biologically active.
THE INNOVATIVE AND BIOLOGICALLY EFFECTIVE
FOLATE SUPPLEMENT
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THE INNOVATIVE AND BIOLOGICALLY EFFECTIVE
FOLATE SUPPLEMENT
For more information on the product or to know where to find it, fill out the form with your details and we will provide you with the appropriate answers as soon as possible.
BIBLIOGRAPHY
1. Patanwala I et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014
2. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006
3. Bailey LB et al. Folate metabolism and requirements. J Nutr. 1999
4. Mazza A. et al. Nutraceutical approaches to homocysteine ​​lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. Biol Regul Homeost Agents 2016
5. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotic. 2014
6. Jamil K. Clinical Implications of MTHFR Gene Polymorphism in Various Diseases. Biol Med. 2014
7. Seremak-Mrozikiewicz A et al. The significance of 1793G> A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett. 2010
8. 5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility. Arthur Clément, Yves Menezo, Marc Cohen, Dominique Cornet, Patrice Clément.
9. Assist Reprod Genet. 2018 Aug; 35 (8): 1431-1435. doi: 10.1007 / s10815-018-1225-2. Epub 2018 Jun 7. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.
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BIBLIOGRAPHY
1. Patanwala I et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014
2. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006
3. Bailey LB et al. Folate metabolism and requirements. J Nutr. 1999
4. Mazza A. et al. Nutraceutical approaches to homocysteine ​​lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. Biol Regul Homeost Agents 2016
5. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotic. 2014
6. Jamil K. Clinical Implications of MTHFR Gene Polymorphism in Various Diseases. Biol Med. 2014
7. Seremak-Mrozikiewicz A et al. The significance of 1793G> A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett. 2010
8. 5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility. Arthur Clément, Yves Menezo, Marc Cohen, Dominique Cornet, Patrice Clément.
9. Assist Reprod Genet. 2018 Aug; 35 (8): 1431-1435. doi: 10.1007 / s10815-018-1225-2. Epub 2018 Jun 7. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.
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