What is an active folate:
The terms “folic acid” and “folate” both derive from the Latin “folium”, which means leaf and are two ways of indicating vitamin B9. In fact, leafy vegetables are among the best dietary sources of folates.
Although frequently “folic acid” and “folates” are used as synonyms, the two terms must be distinguished.
While folate is the vitamin in its biologically active and natural form, folic acid is the synthetic form of folates. Therefore Folipram is the biologically active form of folate, which is naturally present in our body and represents 98% of plasma folates.
Folipram does not need to be biotransformed by the methylene-tetrahydrofolatoreductase enzyme (MTHFR). Therefore, with its intake, its bioavailability is not limited by the saturation of this enzyme and its intake does not involve the presence of non-metabolized forms of folate in the blood.
Folipram is the metabolically active form of folic acid and is able, through the transfer of a methyl group, to reconvert homocysteine into methionine and to perform all the biological and health functions of folate even in the presence of a genetic deficit.