Folipram2021-11-17T12:05:12+01:00

THE ACTIVE AND EFFECTIVE FOLATE

The food supplement based on folic acid Gluten Free, Lactose Free, Sugar Free, with Sweeteners and Citrus Flavor.
Designed for:

  • Pregnancy and breastfeeding

  • Male and female fertility

  • Babies and children

  • Mood and brain health

  • Aging

  • Cardiovascular protection

Find out more on Folipram

THE ACTIVE AND EFFECTIVE FOLATE

The food supplement based on folic acid Gluten Free, Lactose Free, Sugar Free, with Sweeteners and Citrus Flavor.
Designed for:

  • Pregnancy and breastfeeding

  • Male and female fertility

  • Babies and children

  • Mood and brain health

  • Aging

  • Cardiovascular protection

Find out more on Folipram

What is an active folate:

The terms “folic acid” and “folate” both derive from the Latin “folium”, which means leaf and are two ways of indicating vitamin B9. In fact, leafy vegetables are among the best dietary sources of folates.
Although frequently “folic acid” and “folates” are used as synonyms, the two terms must be distinguished.
While folate is the vitamin in its biologically active and natural form, folic acid is the synthetic form of folates. Therefore Folipram is the biologically active form of folate, which is naturally present in our body and represents 98% of plasma folates.

Folipram does not need to be biotransformed by the methylene-tetrahydrofolatoreductase enzyme (MTHFR). Therefore, with its intake, its bioavailability is not limited by the saturation of this enzyme and its intake does not involve the presence of non-metabolized forms of folate in the blood.
Folipram is the metabolically active form of folic acid and is able, through the transfer of a methyl group, to reconvert homocysteine into methionine and to perform all the biological and health functions of folate even in the presence of a genetic deficit.

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What is an active folate:

The terms “folic acid” and “folate” both derive from the Latin “folium”, which means leaf and are two ways of indicating vitamin B9. In fact, leafy vegetables are among the best dietary sources of folates.
Although frequently “folic acid” and “folates” are used as synonyms, the two terms must be distinguished.
While folate is the vitamin in its biologically active and natural form, folic acid is the synthetic form of folates. Therefore Folipram is the biologically active form of folate, which is naturally present in our body and represents 98% of plasma folates.

Folipram does not need to be biotransformed by the methylene-tetrahydrofolatoreductase enzyme (MTHFR). Therefore, with its intake, its bioavailability is not limited by the saturation of this enzyme and its intake does not involve the presence of non-metabolized forms of folate in the blood.
Folipram is the metabolically active form of folic acid and is able, through the transfer of a methyl group, to reconvert homocysteine into methionine and to perform all the biological and health functions of folate even in the presence of a genetic deficit.

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Pregnancy and Breastfeeding(1-2)

Studies have shown that a low dietary intake of folate increases the risk of congenital malformations in the unborn child. Folipram may be particularly useful in providing the active form of folate whose beneficial effects are important for pregnancy, lactation and healthy child development.

Women and men infertility (7-8)

Low blood folate levels are associated with high levels of homocysteine, which can interfere with the early stages of human reproduction and make conception difficult. Folipram active folate supplementation may be an effective aid in infertility, as demonstrated in a study of couples with fertility problems and recurrent miscarriages. Treatment with active folate has been shown to improve the success rate of carrying a pregnancy to term in couples with recurrent miscarriages (+ 86.7%).

Mood and Brain Health(4-8)

Folate is involved in the production of key neurotransmitters in the brain and its deficiency can affect mood. Supplementation with Folipram can help improve mood and support people with depressive disorders.

Infants and Children(1-4)

Folate is a key nutrient when human cell growth is very active and folate deficiency can slow the overall growth rate.
In infants, children and adolescents, Quatrefolic® may be recommended to prevent anaemia, to support tissue growth, normal brain development and function, red blood cells and energy production.

Aging(6)

The folate deficiency in the elderly population is about 30%. High levels of homocysteine are associated with cardiovascular problems and cerebrovascular insufficiency.

Folate deficiency is also a recognised factor in cognitive decline and incipient dementia.

Protezione Cardiovascolare(4)

L’iperomocisteinemia è frequentemente associata con la deficienza di folati e questo determina lo stretto collegamento tra folati e iperomocisteinemia e rischio cardiovascolare.

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THE ACTIVE AND EFFECTIVE FOLATE

FOLIPRAM is the biologically active form of folate which can be used without any metabolic activation. FOLIPRAM is easily absorbed and is immediately active for its biological effects.

ASK YOUR TRUSTED PHARMACIST FOR FOLIPRAM

THE ACTIVE AND EFFECTIVE FOLATE

FOLIPRAM is the biologically active form of folate which can be used without any metabolic activation. FOLIPRAM is easily absorbed and is immediately active for its biological effects.

ASK YOUR TRUSTED PHARMACIST FOR FOLIPRAM

F.A.Q.

Why our body needs Folate?2021-11-17T12:08:34+01:00

The water-soluble vitamin that constitutes folate (vitamin B9) is important as it acts in favor of the synthesis of DNA which regulates cell division. In the case of rapid growth, and therefore in particular at the beginning of pregnancy, the need for folic acid increases. In general, moreover, this vitamin participates in the biosynthesis of many substances useful for health.

A folic acid deficiency occurs in women mainly in the form of anemia and an increase in homocysteine levels in the blood.

Folates in pregnancy, when to take them?2021-11-17T12:10:43+01:00

The intake of active folates before pregnancy is highly recommended as it is essential in the production of new cells. Their deficiency could compromise the normal evolution of an embryo and, in particular, the formation of the vertebral column and spinal cord. It is therefore essential to prevent birth defects.
In pregnancy, therefore, in addition to improving your lifestyle by following a healthy diet, it is important to take a folic acid supplement. The folates present in Folipram are biologically active.

THE INNOVATIVE AND BIOLOGICALLY EFFECTIVE
FOLATE SUPPLEMENT

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    THE INNOVATIVE AND BIOLOGICALLY EFFECTIVE
    FOLATE SUPPLEMENT

    For more information on the product or to know where to find it, fill out the form with your details and we will provide you with the appropriate answers as soon as possible.

      Full Name*

      E-mail*
      Your Message

      BIBLIOGRAPHY

      1. Patanwala I et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014
      2. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006
      3. Bailey LB et al. Folate metabolism and requirements. J Nutr. 1999
      4. Mazza A. et al. Nutraceutical approaches to homocysteine ​​lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. Biol Regul Homeost Agents 2016
      5. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotic. 2014
      6. Jamil K. Clinical Implications of MTHFR Gene Polymorphism in Various Diseases. Biol Med. 2014
      7. Seremak-Mrozikiewicz A et al. The significance of 1793G> A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett. 2010
      8. 5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility. Arthur Clément, Yves Menezo, Marc Cohen, Dominique Cornet, Patrice Clément.
      9. Assist Reprod Genet. 2018 Aug; 35 (8): 1431-1435. doi: 10.1007 / s10815-018-1225-2. Epub 2018 Jun 7. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.

       

      BIBLIOGRAPHY

      1. Patanwala I et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014
      2. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006
      3. Bailey LB et al. Folate metabolism and requirements. J Nutr. 1999
      4. Mazza A. et al. Nutraceutical approaches to homocysteine ​​lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. Biol Regul Homeost Agents 2016
      5. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotic. 2014
      6. Jamil K. Clinical Implications of MTHFR Gene Polymorphism in Various Diseases. Biol Med. 2014
      7. Seremak-Mrozikiewicz A et al. The significance of 1793G> A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett. 2010
      8. 5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility. Arthur Clément, Yves Menezo, Marc Cohen, Dominique Cornet, Patrice Clément.
      9. Assist Reprod Genet. 2018 Aug; 35 (8): 1431-1435. doi: 10.1007 / s10815-018-1225-2. Epub 2018 Jun 7. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.

       

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